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Serotonin-1A receptor stimulation mediates effects of a metabotropic glutamate 2/3 receptor antagonist, 2S-2-amino-2(1S,2S-2-carboxycycloprop-1-yl)-3-(xanth-9-yl)propanoic acid (LY341495) and an N-methyl-D-aspartate receptor antagonist, ketamine, in the novelty-suppressed feeding test

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Findings include: Accelerated wound closure rates in multiple animal models across all regenerative components KPV-mediated inflammation control: Reduced inflammatory cell infiltration (leukocytes, mast cells) Enhanced re-epithelialization and granulation tissue formation Improved collagen deposition and organization in healing wounds Smaller scar formation demonstrated in KPV studies, complementing tissue repair components Antimicrobial effects from KPV against S

10.1038/sj.gt.3301498 Gene Ther