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SAM is produced within the body and obtains its required methyl group from methylcobalamin underlining the importance of methylcobalamin as a central supplier of methyl groups

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Characterization of procaspase-1 cleavage in mammalian cells To determine whether X(PC) can cleave full-length procaspase-1 in a cellular context, we transfected hemagglutinin (HA)-tagged procaspase-1-Cys285Ala into HEK293T cells and incubated lysates with decreasing doses of purified proteases (Extended Data Fig

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