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The compound functions as a synthetic D-retro-inverso peptide carrying a shortened version of the FOXO4 segment that binds to p53, acting as a competitive inhibitor of this critical protein-protein interaction
Although these findings are encouraging, they come primarily from small clinical studies and have yet to be confirmed by large independent trials
10.1093/jnci/dji316 J
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Moreover, mesoporous silica nanoparticles particularly SBA-15 have been extensively used to encapsulate and deliver a wide range of cancer drugs, including hydrophobic and hydrophilic drugs, peptides, and nucleic acids due to their biocompatibility, stability, and ease of functionalization [2]
The discontinuation profile proves more favorable than retinoids showing rapid rebound and high dependency, while similar to vitamin C and niacinamide demonstrating moderate benefit retention and low dependency patterns
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