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A dose-response analysis across 39 randomised trials and 33,354 participants found that nausea risk rose fastest across the lowest doses, then showed a tendency to plateauing at highest dosages

The extended hold approach gives the medication more time to reach full effectiveness at each level before assuming a higher dose is needed

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In-vitro studies are valuable for understanding mechanisms

Five clinical trials involving adult patients have been evaluated in a systematic review with positive results (100)

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