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Plant polyphenols, such as resveratrol found in grapes and red wine, can activate key regulatory pathways involving sirtuins and the peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1), which promote the expression of genes involved in mitochondrial function 15,16,17

GHRPs (growth hormone-releasing peptides) like Ipamorelin are ghrelin mimetics that activate the GHS-R receptor, a different receptor pathway that also triggers GH release

The other works from the bottom up, mimicking a gut hormone that slows digestion, regulates blood sugar, and quietly rewires the appetite centers of the brain

For a one-year therapy, a patient needs only 13 pens containing 4 weekly injections compared to 52 single-use autoinjectors

A 2021 comparative trial published in the Journal of Endocrinology found this combination produced 2.3 greater IGF-1 elevation than either compound alone at equivalent doses, with no increase in cortisol or prolactin spillover

Onnit does well with testing measures, but the lack of greater transparency is a disappointment for Alpha BRAINs overall safety measures