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Impaired L-carnitine synthesis by the kidneys may also contribute to the potential for carnitine deficiency in patients with end-stage renal disease undergoing hemodialysis

10.1016/j.cell.2012.09.016 37

Tesamorelin , a stabilized GHRH analog , binds the GHRH receptor on pituitary somatotrophs to stimulate endogenous growth hormone release and elevate IGF-1

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Subgroup analyses based on study duration, L-carnitine dose, sample size, age, and health status were conducted to identify potential sources of heterogeneity