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To address this limitation, we generated a mutant library through UV radiation and identified mutants with enhanced glutathione levels using an acrolein resistancemediated screening approach

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Each of these systems is compromised to varying degrees in T21 due to gene overexpression, oxidative stress, and immune dysregulation, making them ideal targets for metabolic restoration

10.1136/bmj-2023-076410 91 YenF.-S.HouM.-C.Cheng-ChungW

Med Sci Monit (2020) 26:e920989