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CagriSema is a once-weekly combination therapy of cagrilintide and semaglutide (the two peptides are mixed together in one injection)
Of those GI-related visits, about 15% resulted in hospitalization
Normal-transit constipation: Stool moves through the colon at a normal rate, but you still experience bowel movement trouble
Disclaimer This article is for informational purposes only and does not constitute medical advice
Waseem MH, Abideen Z, ul, Shoaib A, Rehman N, Osama M, Sajid B, et al
Several mechanisms including glucotoxicity, lipotoxicity, altered secretion of adipokines/cytokines, hepatokines (mainly higher circulating fetuin-A levels), stimulation of multiple inflammatory pathways, reduced bile-acid synthesis, endoplasmic reticulum stress, increased oxidative stress, mitochondrial dysfunction and alterations in gut microbiota/gut-derived endotoxins, in a complex interplay with genetic predisposition, drive the evolution of inflammation, hepatocellular injury and fibrosis [2426]
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