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Glucagon receptor activation in Retatrutide increases energy expenditure beyond appetite suppression effects

Investors decided the Mounjaro story was played out

Or perhaps persistent fatigue makes it a struggle to even start your workouts

Better sleep means better recovery, which means better results from your training

This phenomenon is known as the rebound effect, where symptoms like increased appetite, elevated blood sugar levels, and changes in cardiovascular health reappear once the medication is discontinued

Jan 9, 2026 10 min read READ MORE Fitness Move Through the Tired Days: How to Work Out When Youre Tired on GLP-1s Feeling low energy while using GLP-1 medications