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Low-to-moderate doses used in cycles, with breaks to allow the system to normalize, have a very different metabolic footprint than relentless, high-dose administration
While all three have some similarities in their mechanisms of action, potency, and potential outcomes from a clinical perspective, they also have some significant differences in terms of selectivity and side effects
References Park, M.-R., Seo, B.-B., & Song, S.-C
The side effects
were the first to reveal the negative association between the expression of miR-199a-3p and mTOR, c-Met and Stat3 (Duan et al., 2015)
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