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Here, we combine our APAP model [10] with the one-carbon and glutathione model described in Methods

doi: 10.1073/pnas.1500722112 204 HammondMEHayesDFWolffACManguPBTeminS

Differences in metabolic characteristics between naive and activated DCs were identified, and pathway-enrichment analysis revealed three significantly altered pathways, including the TCA cycle, -linolenic acid metabolism, and valine, leucine, and isoleucine degradation (110)

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Detoxification problems : Sensitivity to toxins, such as alcohol or pollutants

Additional regulatory elements include PCTR1 (48), circEXOC5 (47), and AUF1 (46)