Even though the market offers specially modified oral versions, their absorption (bioavailability) is significantly lower than with injections, unpredictable, and still not sufficiently clinically verified
This can prove beneficial in people with methylation disorders or gene variations like MTHFR
Dulaglutide (Trulicity), another once-weekly GLP-1 agonist, reports injection site reaction rates of approximately 0.7% in its FDA label
Wegovy requires weekly injections that slowly increase in dosage, so the patient must also be able to either administer the injection themselves or have access to a pharmacist or someone who is qualified to administer the injections reliably every single week to ensure that the treatment and medication are as effective as possible
In this way, the GST-GSH interaction could act as an anchor, holding the therapeutic protein on a hydrogel until MMP-2 cleaves the therapeutic protein from the GST anchor
In a third trial comparing participants using tirzepatide with those on Tresiba (insulin degludec), the tirzepatide group again had greater reductions in A1c levels