Authors: Thomas Kruse, Jakob Lerche Hansen, Kirsten Dahl, Lauge Schffer, Ulrich Sensfuss, Christian Poulsen, Morten Schlein, Ann Maria Kruse Hansen, Claus Bekker Jeppesen, Charlotta Dornonville de la Cour, Trine Ryberg Clausen, Eva Johansson, Simone Fulle, Rikke Bjerring Skyggebjerg, Kirsten Raun URL: This paper details the medicinal chemistry efforts that led to the design and synthesis of cagrilintide, a long-acting amylin analogue for the treatment of obesity
Microbial infection can escape from the immune system to form virulence factors such as oxygen free radicals, nitric oxide, and matrix metalloproteinases to promote the occurrence of tumors
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Patients who inherit loss-of-function variants in the HPRT1 gene exhibit not only severe symptoms of gout but also a severe malfunction of the nervous system
17 A meta-analysis also found reduced glutathione, specifically in the occipital cortex of the brain, in major depression