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While not studied in clinical trials, some users report better tolerability splitting their weekly dose
J., Bell, M
Injection-site irritation can occur with any shot, and ingredient-specific reactions are possible
We measure serum vitamin B12 levels before starting and at follow-ups
So people at greatest risk for deficiency include those with low stomach acid (e.g., older adults and people on proton pump inhibitors or antacids) or low IF production (known as pernicious anemia), people on medications that interfere with B12 absorption (such as metformin), people who have had gastric surgery, those with GI conditions that impair nutrient absorption (like celiac or Crohn's disease), and people on vegan and vegetarian diets
