4151-A UNMET SYSTEMIC THERAPY NEED FOR CHILD-PUGH CLASS B PATIENTS WITH UNRESECTABLE HEPATOCELLULAR CARCINOMA COMPARISON OF ATEZOLIZUMAB PLUS BEVACIZUMAB AND LENVATINIB Hideko Ohama 1,2,3 , Atsushi Hiraoka 1,2 , Toshifumi Tada 2 , Masashi Hirooka 2 , Kazuya Kariyama 2 , Ei Itobayashi 2 , Tsuji Kunihiko 2 , Toru Ishikawa 2 , Hidenori Toyoda 2 , Takeshi Hatanaka 2 , Satoru Kakizaki 2 , Atsushi Naganuma 2 , Tomomitsu Matono 2 , Fujimasa Tada 1,2 , Kazuhiro Nouso 2 , Yoichi Hiasa 2 and Takashi Kumada 2 , (1)Ehime Prefectural Central Hospital, (2)Relpec Study Group and HCC 48 Group, (3)Takarazuka City Hospital Background: Systemic treatment is generally recommended for unresectable hepatocellular carcinoma (uHCC) patients with Child-Pugh (CP)-A status

However, chronically infected individuals who become immunosuppressed due to corticosteroid treatment or infection with HTLV-1 can develop hyperinfection syndrome, which can affect several organs, a condition that can be life-threatening [12, 13]
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29 Epigenetic dysregulation further contributes to immune evasion and therapy resistance
Further doseresponse and steady-state administration studies will be required to optimize the dosing schedule for future trials to evaluate therapeutic efficacy