Clinical trials in the SURPASS program demonstrated that Mounjaro achieved higher glycaemic control benchmarks than semaglutide 1mg
To feel your best on these medications, you can take some practical steps: Eat smaller meals
Fung TC, Olson CA, Hsiao EY
Many people feel fine at first, then hunger surges later In the STEP 1 extension, participants regained about two thirds of prior weight loss in the year after stopping A 2026 BMJ meta-analysis estimated average regain of roughly 0.4 kg per month after stopping weight-loss medications, with return toward baseline projected within 1.5 to 1.7 years The same meta-analysis found no evidence that more intense behavioural support during treatment meaningfully changed the rate of regain after stopping Weight regain is often accompanied by reversal of cardiometabolic improvements, not just scale change Summary Stopping semaglutide should be understood as a biology handoff
Contraceptive options and dose-escalation timing should be reviewed with a clinician
Additionally, they said that semaglutide and other GLP-1 medications regulate dopaminergic pathways underlying reward sensitivity, which are at least partly responsible for their weight-loss action and their putative activity against addictive behavior. Deborah B