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Once-weekly semaglutide versus placebo in adults with increased fracture risk: a randomised, double-blinded, two-centre, phase 2 trial. eClinicalMedicine
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Indeed GLP-1(9-36) pharmacodynamics studies in human might be partially explained by the activity of its metabolites (128)
Focus on assessing GI tolerance, injection site reactions, and baseline appetite changes
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Until those data mature, clinicians should frame Wegovys MASH indication as evidencesupported for histologic response but still under confirmatory evaluation for hard liver outcomes. Safety profile and risk management Safety considerations for Wegovy are dominated by its GLP1 class effects and includes both common, generally manageable GI symptoms and less frequent but clinically significant risks
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