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The interplay of glucagon-like peptide-1 receptor trafficking and signalling in pancreatic beta cells
For replacement experiments, isogenic HeLa cell lines were induced with tetracycline overnight prior to siRNA transfection
Blocking ATP synthase with oligomycin or targeting P2X4 receptors eliminated the migration-promoting effects observed in cell culture studies
10.1196/annals.1320.003
Taken together, these data demonstrate that mitochondrial function is intrinsically linked to 5FU sensitivity, and that its inhibition may provide an opportunity to increase 5FU efficacy
One notable exception is oral semaglutide (Rybelsus) for diabetes treatment, which uses special absorption enhancement technology
