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In a study in 60 abdominally obese subjects with diminished GH, tesamorelin led to a reduction of 3.7lb in body fat from after 52 weeks of 2mg/daily administration

Notably, this effect can be reversed by c-Myc overexpression

Patients with T2DM initiating GLP-1 RAs or metformin as first-line monotherapy were included (87,229 matched patients per cohort).The researchers found that compared with metformin, GLP-1 RA use was associated with a significantly lower risk for overall dementia, Alzheimer disease, and nonvascular dementias (adjusted hazard ratios, 0.90, 0.88, and 0.75, respectively)

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