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This aligns with findings from SURPASS-CVOT, which showed no meaningful additive effect on MACE compared to an older GLP-1 receptor agonist, and with findings of a potential greater protection in heart failure that could be compatible with more pronounced weight loss mediated by GIP 16,22

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doi: 10.1016/j.cell.2016.12.039 16 CostelloLCFranklinRB

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J Pediatr 145:555560 Whl E, Haffner D, Offner G, Broyer M, vant Hoff W, Mehls O