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In animal models, psychosocial stress-induced (neuro) inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression
doi:10.1080/01635581.2012.690928 6
Then of course there is the third group, the one you likely do not meet in your clinic until its too late
Cocaine metabolites
Cho YS, Lee J, Lee TH, Lee EY, Lee KU, Park JY, Moon HB: Alphalipoic acid inhibits airway inflammation and hyperresponsiveness in a mouse model of asthma
Side effect comparison: Nausea: Similar rates between the two compounds Vomiting: Cagrilintide significantly lower (OR 0.38) Diarrhea: Comparable rates Constipation: Similar Injection site reactions: Cagrilintide substantially higher Discontinuation due to AEs: Cagrilintide much lower (1% vs approximately 5-7%) The takeaway: if vomiting was your main problem on semaglutide, cagrilintide may be worth exploring
