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However, an increasing number of early-phase trials of therapies for symptoms, including cognitive enhancers and agents for relieving BPSD, are being conducted

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To test this hypothesis, we constructed the gpoA Cys36Ala mutant, which demonstrated a higher susceptibility to H 2 O 2 in reference to the wt strain, a similar phenotype displayed by the gpoA mutant (Fig 3B, Fig S2)

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Limitation: direct measurement of intracellular NAD+ in different tissues in humans is technically challenging