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A 2025 meta-analysis found that semaglutide increased the relative risk of cholelithiasis (gallstones) by 1.92 , liraglutide by 1.75 , and tirzepatide by 1.36

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According to FDA prescribing information, these adverse effects were dose-dependent and contributed to treatment discontinuation in clinical trials

In both these instances, conditions tend to improve due to body weight dropping making it important to recognise which benefits are due to weight loss rather than any specific pharmacological action

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