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This is still a powerful hormone-based therapy

Eur J Endocrinol 171(3):R123R135 Miller JC, Thomson CD, Williams SM et al (2012) Influence of the glutathione peroxidase 1 Pro200Leu polymorphism on the response of glutathione peroxidase activity to selenium supplementation: a randomized controlled trial

However, chelating agents like EDTA should be avoided in GHK-Cu formulations, as they competitively bind copper and destabilize the peptide-metal complex, resulting in reduced biological activity

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The concentration of GSH is at high levels, and GSSG and ROS are at depressed levels to maintain redox homeostasis in cardiomyocytes