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Monotherapy protocols are commonly initiated at 0.6 mg per week and escalated to a maximum studied dose of 4.5 mg as tolerated
However, research suggests that high-dose oral B12 supplements work just as well as B12 shots for raising B12 levels in people with a deficiency
There's also an osmolality mismatch, meaning the concentration of dissolved particles in the injection doesn't match your interstitial fluid
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