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Those who took a placebo lost just 2.3% of their body weight
What actually happens is the GLP-1 agonist starts slowing gastric emptying while a large bolus of food is entering the stomach
Moreover, this hypothesis agrees with results reported during the preparation of this manuscript that demonstrate that GLP-1R undergoes endocytosis independent of arrestin and is mediated by both clathrin- and caveolae-dependent mechanisms (Moo et al., 2025)
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Blood Sugar Changes While GLP-1 medications dont typically cause hypoglycemia on their own, reduced food intake during treatment may lead to blood sugar dips that trigger headaches
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