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Hypertens Res 48 , 31593171 (2025)
This decline contributes to thinner skin, reduced bone density, increased visceral fat, and slower recovery from injury (Rudman et al., N Engl J Med 1990)
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Notably, OCT1, PMAT, and SERT are the principal transporters facilitating metformins intestinal absorption in intestinal cells, contributing to 25%, 20%, and 20% of its transport, respectively (Han et al., 2015)
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