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This is an important consideration for future studies due to the larger effect size in risk of PDAC observed in patients with new onset compared with longstanding diabetes (typically defined as 3 years duration) 46

4.2 Central nervous system adaptations to taste in obesity Certain brain regions are responsible for processing sensory information through visual, olfactory, and auditory pathways, as well as gustatory signals

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The severity and timing of these side effects can vary based on individual genetic factors, specific chemotherapy plans, and the total amount of drugs used [3]

Based on this Knudsen attempted to persuade Novo Nordisk to consider investing in the drug to treat obesity