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A dose-dependent inverted U-shaped response to DHEAS is observed on tests of learning and memory function in male mice (317, 318)
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HER2 transmembrane domain (TMD) mutations (V659/G660) that stabilize homo- and heterodimerization are rare oncogenic drivers in lung adenocarcinoma that respond to afatinib
For individuals with sensitive stomachs, taking tablets with a small amount of water or immediately before a light meal may help prevent any digestive discomfort
Treatment begins with a dose-escalation schedule (0.6 mg weekly increments to 3.0 mg as tolerated) and should be discontinued after 12 weeks at the 3.0 mg dose if at least 5% weight loss has not been achieved
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