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Combining them raises the risk of severe digestive side effects with no added clinical benefit

In clinical trials, most patients undergoing the injections lost up to 15% of their body weight (up to 20 pounds per month) compared to other weight loss medications

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Because oral absorption is inefficient, studies show it often takes up to 50 mg daily to match the clinical results of 22.4 mg weekly injections (Ozempic and Wegovy)