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The amino acid sequence is in the public domain and there is no composition-of-matter patent worth pursuing, so no commercial sponsor will fund the hundreds of millions a Phase IIIII development programme costs for a compound it cannot exclusively monetise

Whilst local injection of methyl-B12 appears to be effective in relieving herpetic pain alongside lidocaine injections, there is at present no evidence that systemic B12, either i.m

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Many companies claim third-party tested, but testing only matters when the laboratories are credible and the results are actually reviewed

Larger volumes can cause discomfort or poor absorption