In topical cosmetic use, GHK-Cu is generally well tolerated
NSL literature pointer PMID 7263094 L-Carnitine laboratory index [PMID: 7263094] National Science Labs indexing note for PMID 7263094: review the PubMed methods, models, and limitations before citing
Evidence gaps No published human randomized trial has evaluated injectable GHK-Cu for cosmetic, hair, or wound endpoints
For some analyses metabolites absolute quantifications were divided by the creatinine concentration, also derived by the IVDr platform from the 1 H-NMR spectra
That slow release is what supports once weekly dosing and steady appetite control across the whole week
In October 2024, the FDA declared that tirzepatide was no longer in shortage, and shortly after in February 2025 announced the same for semaglutide