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doi: 10.3389/adar.2023.10901 Received 13 September 2022 Accepted 09 January 2023 Published 18 January 2023 Volume 3 - 2023 Edited by Emmanuel Onaivi, William Paterson University, United States Reviewed by Qing-Rong Liu, National Institute on Aging (NIH), United States Syed Ali, National Center for Toxicological Research (FDA), United States Updates Copyright 2023 Virmani

Benefits of GHK-CU that have been established to date Tightens loose skin and reverses thinning of aged skin Repairs protective skin barrier proteins Improves skin firmness elasticity and clarity Reduces fine lines, depth of wrinkles, and improves structure of aged skin Reduces photodamage, mottled hyperpigmentation, skin spots and lesions Improves overall skin appearance Protects skin cells from UV radiation Reduces inflammation and free radical damage Increases hair growth and thickness and enlarges hair follicle size

Freet et al., 2025)

Here we report high-resolution cryo-electron microscopy (cryo-EM) structures of human GLP-1RG s in complex with compound 2 alone, with both compound 2 and endogenous peptidic agonist GLP-1, or with compound 2 and a small molecule agonist (LY3502970)