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Until Phase 3 data are published and regulatory review is completed, conclusions about long-term efficacy and safety must remain cautious
Similarly, it has been found that FUNDC1 can interact with Drp1 and Opa1, whereas under stress, FUNDC1 dephosphorylates to separate from OPA1 and binds to Drp1, and FUNDC1 recruitment to Drp1 is enhanced on the mitochondria-associated endoplasmic reticulum membranes (MAMs), promoting mitochondrial fission and mitophagy [91, 92]
But sometimes a different compound, dose, or approach is needed
There's no predicting which direction the medications will go, and it depends both on the specific medication and the individual
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