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nevertheless, their most pronounced effect in obesity is appetite reduction through central nervous system (CNS) mechanisms, mainly within the hypothalamus [35]

References Ohno T, et al

Highly palatable, high-calorie foods typically trigger a significant dopamine release, creating a pleasurable sensation that encourages repeat consumption

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This prolongation of the sensation of fullness can significantly reduce overall calorie intake, making it easier for patients to adhere to their dietary plans

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