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The company's focused pipeline strategy and proprietary understanding of senescent cell biology in ocular tissue position it as a potential first-mover in one of the most commercially attractive senolytic indications, given the enormous unmet need and the demonstrated willingness of ophthalmology patients and payers to support innovative therapies

The peptide itself promotes angiogenesis through VEGFR2 signaling

Effect focus: Both slow gastric emptying and increase satiety, but via complementary receptors

Xiong, W

Squadrito GL, Cueto R, Splenser AE, Valavanidis A, Zhang H, Uppu RM, et al

Its most consistently documented mechanism involves VEGFR2 activation and Akt-eNOS signaling, promoting angiogenesis in connective tissue research models (Hsieh et al., Journal of Molecular Medicine, 2017, DOI: 10.1007/s00109-016-1488-y)