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Diet-induced obese mice were fed with 60 kcal% fat diet (D12492, Research Diets) at age 68 weeks for 3 months
Oxidation: Methionine, cysteine, and tryptophan residues are particularly vulnerable to oxidative degradation
Side effects Despite FDA approval, PHEN/TPM is not approved for obesity pharmacotherapy by the EMA due to cardiovascular safety concerns
Furthermore, early thinning of GCL was evident on OCT
FDA Approval: Semaglutide is fully FDA-approved for weight management, while Tirzepatide is currently approved for diabetes treatment, with its weight-loss indication still pending
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