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Innovative clinical trial designs, including basket, umbrella, platform, and adaptive trials, may accelerate the evaluation of personalized treatment strategies while accommodating the biological complexity of resistance evolution

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To our knowledge, the effect of SGLT-2Is on renal size in patients with diabetes has never been reported

They may also repeat blood tests to assess vitamin B12 levels and other markers related to deficiency, helping determine whether the current injection schedule is meeting the patients medical needs

Signs of dehydration include decreased urination, dark urine, dizziness, rapid heartbeat, and extreme thirst