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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells
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These enzymes are up-regulated or down-regulated depending on cellular glutathione concentrations and exert a similar effect on glutathione itself
10.1096/fj.09-144519 93 KoretsS
Currently there is no clear evidence that supplementation beyond what we get from diet is useful, but there is evidence it may have antiviral effects
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