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Food and Drug Administration (FDA) approved Wegovy as the first treatment to reduce the risk of serious heart problems in overweight and obese adults
Abbreviations HF: Heart failure T2DM: Type 2 diabetes mellitus SGLT2is: Sodium-glucose cotransporter-2 inhibitors GLP-1RAs: Glucagon-like peptide-1 receptor agonists HR: Hazard ratio References Abdul Basith Khan M, Hashim MJ, King JK, Govender RD, Mustafa H, Al Kaabi J
doi:10.1128/ec.00216-06 Bely, M., Renault, P., Da Silva, T., Masneuf-Pomarde, I., Albertin.,W., Moine, V., Coulon, J., Sicard, D., De Vienne, D., & Marullo, P
(Wikipedia) In senescent cells (cells that have permanently exited the cellcycle, accumulate damage, and secrete inflammatory factors), FOXO4 expression goes up and helps bind p53 in the nucleus, preventing p53 from driving those cells into apoptosis
Int J Mol Sci 2022;23
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