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doi: 10.1016/S0024-3205(00)00868-7 108 IresonCRJonesDJLOrrSCoughtrieMWHBoocockDJWilliamsMLet al
And tirzepatide itself has demonstrated significant improvements in metabolic parameters beyond weight loss, so finding an alternative that matches its metabolic profile is challenging
P values are two-sided and not adjusted for multiplicity
Similarly the weight loss seen with Exenatide and some other early GLP-1 drugs was thought too limited to win approval for the treatment of obesity (Gilbert, Rosenthal, March 2024)
The potential benefits include: Substantial weight loss beyond what is typically seen with current medications Improved blood sugar control for people with diabetes Possible reduction in cardiovascular risk factors linked to obesity These promising outcomes have generated excitement among researchers, healthcare providers, and patients seeking new options for difficult-to-manage conditions
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