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Specifically, advise patients to promptly seek medical attention if they develop pain or tenderness, redness, or swelling of the genitals or the area from the genitals back to the rectum, along with a fever above 100.4F or malaise [see Warnings and Precautions (5.4)]
A meta-analysis of 10 trials totaling 71,351 patients extended these findings, showing GLP-1 receptor agonists reduced the composite kidney outcome by 17% across trials
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They are coming off the Category 2 restricted list effective April 23, 2026, with PCAC review of their compounding eligibility scheduled for July 23-24, 2026
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