Cancer cells frequently exhibit elevated levels of receptors such as the folate receptor, transferrin receptor, epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), and integrins, which can be exploited for receptor-mediated endocytosis
Atomic absorption spectroscopy or ICP-MS on a digested sample gives total copper independent of the peptide, and combining that with peptide content establishes stoichiometry rather than assuming it
S.BlackM
Comprehensive Landscape of BRAF Variant Classes, Clonalities, and Co-Mutations in Metastatic Colorectal Cancer Using ctDNA Profiling
The hydrophobicity of the phenylalanine cluster in crevasse, along with the ability of fatty acids longer than octanoic acid (C8:0), such as lauric acid (C12:0) and palmitic acid (C16:0), to activate the ghrelin receptor, initially led to the hypothesis that the fatty acid chain of ghrelin extends through this crevasse into the cell membrane (Matsumoto et al., 2001)
Documentation of the research purpose, careful sourcing, and meticulous record-keeping reflect this research orientation
