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The study, published in Nature Health , covers more than half a decade of posts from nearly 70,000 Reddit users and highlights two main classes of symptoms that warrant further study: reproductive symptoms, including irregular menstrual cycles, and temperature-related complaints, such as chills and hot flashes

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Lung Cancer 2008;59(2):155-163

(31) In one case study, primary hypothyroidism was caused by a deficiency of amino acids while the patient was on a protein-calorie restricted diet