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(STEP 4) Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial JAMA 325(14) 2021PMID: 33755728 PubMed 3 Wilding JPH, Batterham RL, Davies MJ, et al
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Flawless MedSpa recommends that Semaglutide GLP-1 be taken for a minimum of 12 weeks, but many patients find that they need to stay on the shots longer to see continued progress
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Having moderate to severe diabetic retinopathy before starting the medication A history of poorly controlled blood sugar over many years High blood pressure that is not well managed Kidney disease or other diabetes-related complications Very rapid reduction in hemoglobin A1C levels within the first few months Rare cases of sudden, painless vision loss from optic nerve injury have been reported in people using GLP-1 receptor agonist medications
The change in HDL cholesterol was not significant
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