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[3] Laboratory tests typically measure total B12 rather than the active form (holotranscobalamin), which can sometimes lead to misleading results
For example, 1000 mcg is the same as 1 mL of a 1000 mcg/mL solution
Storage Instructions Store the dry solid at -20C, sealed and protected from light and moisture, where it remains stable for extended periods
Intramuscular therapy leads to more rapid improvement and should be considered in patients with severe deficiency or severe neurologic symptoms
Important factors for the loading phase include: Severity of initial deficiency Presence of neurological symptoms Patients overall health status Response to initial doses as assessed through follow-up laboratory tests By following this guideline, doctors can quickly restore vitamin B12 levels
8,9 Table 1 Risk Factors for Vitamin B12 Deficiency A multicenter randomized controlled trial of 390 patients with diabetes mellitus showed that those taking 850 mg of metformin three times per day had an increased risk of vitamin B 12 deficiency (number needed to harm = 14 per 4.3 years) and low vitamin B 12 levels (number needed to harm = 9 per 4.3 years) vs
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