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Brito, M.D., an endocrinologist associated with Division of Endocrinology, Diabetes, Metabolism and Nutrition at Mayo Clinic
This unexpected link between mitochondrial glutathione and m -AAA protease AFG3L2 might lead to new pathophysiological mechanisms under a diverse clinical spectrum of AFG3L2 mutation-associated neurodegenerative disorders that range from ataxia to parkinsonism 29,43
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This hypothesis is further supported by a study [54] which demonstrated that electrical stimulation of afferent renal nerves activates rostral ventrolateral medulla-projecting paraventricular nucleus (PVN) neurons in the hypothalamus
