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Trade-offs include less flexibility in dose adjustment and prolonged exposure if adverse effects develop
Beyond meeting the primary composite kidney outcome, semaglutide was found to have a substantial CV benefit in patients with T2D and CKD
doi:10.1016/j.ophtha.2025.01.016 Marso SP, Bain SC, Consoli A, et al
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However, obesity is one of the biggest risk factors for Type 2 Diabetes
A reduction in the activity of such an enzyme means GLP-1 stays active longer, which extends satiety signals and insulin modulating effects
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