GLP-1 medications are not approved as a replacement for insulin in type 1 diabetes
Despite programs to help people recover, most end up relapsing to their destructive behaviors
On January 4, 2026, Novo Nordisk's data exclusivity for semaglutide expired in Canada
Looking Inside Brain Cells To investigate what occurs inside neurons after semaglutide exposure, researchers led by first author Claire Gao, Ph.D., a postdoctoral fellow at NIHs National Institute of General Medical Sciences (NIGMS), used a fluorescence imaging technique to observe living mouse brain tissue
Semaglutide overcomes this through two structural modifications: an alanine-to-Aib substitution at position 8 (which removes the DPP-4 cleavage site) and the attachment of a C18 fatty diacid chain via a bifunctional linker at lysine position 26
Efficacy in Weight Loss: Semaglutide: Clinical trials have shown that semaglutide can lead to significant weight loss, with users typically experiencing around 15-20% reduction in body weight over a period of 68 weeks
