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Transdermal delivery bypasses the digestive tract, which may benefit people who struggle with pill fatigue, GI sensitivity, or experience skin reactions to adhesive medications at lower rates than oral supplements causing nausea
However, eye drops containing preservatives like benzalkonium ammonium chloride (BAK) may cause corneal epithelial disruption, which would delay the healing of wounds [276]
Its cognitive-enhancing effects build over days to weeks through neuroplasticity mechanismsBDNF upregulation, synaptic remodeling, and gene expression changes
For weight loss on their own, the evidence does not support it
10.1074/jbc.M112.405738 J
Frequently Asked Questions How much MOTS-c should you take per day
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